Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis

• 作者: Hong-Wei Chen Fu-Dong Lu Ying Cheng Yue Jia Liang-Qiu Lu Wen-Jing Xiao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Concise Reports
• 页码范围: 1671-1675
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000309

摘要

An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis.This reaction features the use of organic photosensitizer and low-cost 3d metal catalyst,simple and safe operations,and extremely mild conditions.A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantio-controls from readily available feedstocks(22 examples,up to 93％ yield and 92％ ee).