Enantioselective Synthesis of Tetrahydroquinolines via One-Pot Cascade Biomimetic Reduction

• 作者: Zi-Biao Zhao Xiang Li Mu-Wang Chen Bo Wu Yong-Gui Zhou
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Concise Reports
• 页码范围: 1691-1695
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202000409

摘要

A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one-pot cascade biomimetic reduction.The detailed reaction pathway includes the acid-catalyzed and ruthenium-catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.