Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo [d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid

• 作者: CAI Xu-Min GU Wen LI A-Liang LIN Yu-Ting WANG Shi-Fa WANG Wen-Yan
• 来源期刊: 结构化学
• 年，卷（期）: 2020,（8）
• 页码范围: 1539-1545
• 页数: 7页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-2640

摘要

The title compounds (7a～7g) were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS,1H-and 13C-NMR.The crystal structure of compound 7g determined by single-crystal X-ray diffractio is of monoclinic system,space group P21 with a =12.282(3),b =9.940(2),c =22.656(5) (A),β =103.06(3)°,Z =2,V=2694.4(10) (A)3,Mr =1182.95,Dc =1.458 Mg/m3,S =1.000,μ =1.649 mm-1,F(000) =1216,the final R =0.0791 and wR =0.1853 for 4098 observed reflections (Ⅰ ＞ 2σ(Ⅰ)).The preliminary antibacterial assay showed that compound 7g exhibits significant inhibitory against Bacillus subtilis,Staphylococcus aureus and Methicillin-resistant S.aureus (MRSA) with MIC values of 1.9 ～ 7.8 μg/mL.