Earlier and enhanced rehabilitation of mechanically ventilated patients in critical care: A feasibility randomised controlled trial

• 来源期刊: 中华物理医学与康复杂志
• 年，卷（期）: 2020,（1）
• 所属期刊栏目: 外刊撷英
• 页码范围: 71
• 页数: 1页
• 语种: 中文
• DOI: 10.3760/cma.j.issn.0254-1424.2020.01.103

摘要

BACKGROUND:Systematic reviews of early rehabilitation within intensive care units have highlighted the need for robust multi-centre randomised controlled trials with longer term follow up. This trial aims to explore the feasibility of earlier and enhanced rehabilitation for patients mechanically ventilated for ≥5days and to assess the impact on possible long term outcome measures for use in a definitive trial.METHODS:Patients admitted to a large UK based intensive care unit and invasively ventilated for ≥5 days were randomised to the rehabilitation intervention or standard care on a 1∶1 basis, stratified by age and SOFA score. The rehabilitation intervention involved a structured programme, with progression along a functionally based mobility protocol according to set safety criteria.RESULTS:103 out of 128 eligible patients were recruited into the trial, achieving an initial recruitment rate of 80%. Patients in the intervention arm mobilized significantly earlier (8days vs 10 days, P＝0.035), at a more acute phase of illness (SOFA 6 vs 4, P<0.05) and reached a higher level of mobility at the point of critical care discharge (MMS 7 vs 5, P<0.01)． CONCLUSION:We have demonstrated the feasibility of introducing a structured programme of rehabilitation for patients admitted to critical care.