Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system

• 作者: Guangsheng Luo Jian Deng Kai Wang Pei Xie
• 来源期刊: 中国化学工程学报（英文版）
• 年，卷（期）: 2020,（8）
• 页码范围: 2092-2098
• 页数: 7页
• 语种: 英文

摘要

4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye (2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the man-ufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br2 solution in CHCl3. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5％, which is superior to the industrial standard with 99.5％3-methylanisole conversion at very short residence time and mild reaction temperature.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Pei Xie		1	0	0.0	0.0
2	Kai Wang		1	0	0.0	0.0
3	Jian Deng		1	0	0.0	0.0
4	Guangsheng Luo		1	0	0.0	0.0