S-Trifluoroethyl Benzenesulfonothioate:A Bench-Stable Reagent for Electrophilic Trifluoroethylthiolation

• 作者: Shuai Huang Ziheng Xia Kui Lu Haifeng Lu Chen-Ho Tung Zhenghu Xu
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2020,（12）
• 所属期刊栏目: Concise Reports
• 页码范围: 1625-1628
• 页数: 4页
• 语种: 英文
• DOI: 10.1002/cjoc.202000279

摘要

We report herein a practical approach for synthesis of an electrophilic trifluoroethylthiolation reagent PhS02SCH2CF3(1)from easily available materials.The reaction proceeded through a protonation and nucleophilic substitution cascade of the in situ formed trifluorodiazoethane.This bench-stable reagent could easily be applied to introduce trifluoroethylthio group into small organic molecules.