Increased vitreal levels of interleukin-10 in diabetic retinopathy:a Meta-analysis

• 作者: Bing Jiang Jing-Ling Zou Shigeo Yoshida Wei Tan Ye-Di Zhou
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: diabetic retinopathy INTERLEUKIN-10 META-ANALYSIS vitreal concentration
• 年，卷（期）: 2020,（9）
• 页码范围: 1477-1483
• 页数: 7页
• 分类号: R774.1

摘要

AIM:To conduct a Meta-analysis for the change of interleukin-10(I1-10)concentration in vitreous samples of patients with diabetic retinopathy(DR).METHODS:Systemic search for literature was conducted from the databases of PubMed,Web of Science and Cochrane Library by August 2019.Statistical analyses including standard mean difference(SMD)and its 95%confidence interval(CI)were performed by using RevMan 5.3 software.RESULTS:Totally 194 studies were screened and finally 11 studies were included in the Meta-ana lysis.The concentration of IL-10 in the DR group was higher than in the control group(P=0.003.SMD:0.77.95%CI:0.25-1.28).Significant heterogeneity was found among all studies(P<0.00001,I~2=92%).The subgroup analysis showed that the concentration of IL-10 increased in vitreous samples from patients with DR compared to the non-DR controls(P=0.004.SMD:1.44.95%CI:0.46-2.42).Moreover,the concentration of IL-10 in samples of proliferative diabetic retinopathy(PDR)patients was significantly higher than that of non-proliferative diabetic retinopathy(NPDR)patients(P=0.01.SMD:0.61.95%CI:0.13-1.08).CONCLUSION:The vitreal concentration of IL-10 is significantly increased in patients with DR.Further studies are needed to reveal the mechanisms of IL-10 in DR.