Two Cu(Ⅱ) and Co(Ⅱ)-based Coordination Polymers Based on the N,S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation

• 作者: LI Jiang-Tao LI Jing
• 来源期刊: 结构化学
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: coordination chemistry
• 页码范围: 1849-1854
• 页数: 6页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-2411

摘要

Two new Cu(Ⅱ) and Co(Ⅱ)-based coordination polymers with the chemical formulae of {Cu(L)2]·DMF}n (1) and {[Co(L)2]·2DMF}n (2) have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand,namely[3,4′-bipyridine]-2′-thiol (HL).Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other,and shows 1-D microporous channels along the a axis.Complex 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b axis.CCK-8 was used for the detection of cancer cells.Results indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer cells.The Annexin V-FITC/PI was recommended for cancer cell apoptosis,and the western blot was applied for the detection of PI3K/AKT pathway activation.