Synthesis, Crystal Structure and Bioactivity Evaluation of a Heterocyclic Compound

• 作者: ZHANG Peng ZHAO Xiao-Mei
• 来源期刊: 结构化学
• 年，卷（期）: 2020,（10）
• 所属期刊栏目: medicinal structural chemistry
• 页码范围: 1892-1897
• 页数: 6页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-2682

摘要

The heterocyclic compound 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (1),designed using 2-chloro-6-methylaniline (2) as the start material,was successfully obtained via multiple synthesis route and finally characterized by IR,1H NMR,and single-cystal X-ray crystallography.To select the suitable candidates for tissue regeneration,the induction activity of the compound on the dental pulp mesenchymal stem cells (DP-MSCs) was evaluated.Firstly,the DP-MSCs cells were isolated and the cell colon formation ability was measured after compound treatment with cell colony determination.After that,the RT-PCT assay was conducted and the relative expression level of the genes related with cell osteogenesis and proliferation was further detected.