Mechanical properties, biodegradability and cytocompatibility of biodegradable Mg-Zn-Zr-Nd/Y alloys

• 作者: Dan Zhang Lili Tan Qiang Wang Shi Jin Xiaopeng Lu Yang Zhang Ying Liu
• 来源期刊: 材料科学技术（英文版）
• 年，卷（期）: 2020,（12）
• 页码范围: 190-201
• 页数: 12页
• 语种: 英文

摘要

Biodegradable magnesium alloys have been turned out to be a promising candidate for orthopedic applications.In this study,the mechanical properties,degradation behavior and cytocompatibility of MgZn-Zr-Nd and Mg-Zn-Zr-Y alloys were studied in comparison with pure Mg.Mechanical tests showed that the strength and ductility of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were excellent.The corrosion resistance analyzed by electrochemical test and immersion test in alpha modified eagle (α-MEM) medium with 10％ fetal bovine serum (FBS) revealed the degradation of Mg-Zn-Zr-Nd and Mg-Zn-Zr-Y alloys were faster than pure Mg at an early stage but slowed down after long time immersion.The metal ion concentrations were consistent with the corrosion rate.Mg-Zn-Zr-Nd alloy shows better mechanical properties than pure Mg and better corrosion resistance than Mg-Zn-Zr-Y alloy.The direct and indirect in vitro tests with MC3T3-E1 cells demonstrate that Mg-Zn-Zr-Nd shows the best cytocompatibility and osteogenesis.The results suggest that Mg-Zn-Zr-Nd alloy shows an ideal combination of mechanical,corrosive and biological properties.In summary,these results implying the Mg-Zn-Zr-Nd alloy has great potential to benefit the future development of orthopedic applications.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Qiang Wang	中国科学院金属研究所	3	0	0.0	0.0
2	Shi Jin	中国科学院金属研究所	1	0	0.0	0.0
3	Dan Zhang	中国科学院金属研究所	1	0	0.0	0.0
4	Xiaopeng Lu	中国科学院金属研究所	1	0	0.0	0.0
5	Yang Zhang	中国科学院金属研究所	1	0	0.0	0.0
6	Lili Tan	中国科学院金属研究所	1	0	0.0	0.0
7	Ying Liu	中国科学院金属研究所	1	0	0.0	0.0