Rare-earth doped luminescent nanomaterials are attractive and have many potential applications in health, energy, information and safety area [1].Similar to most chemical processes, the process to synthesize luminescent nanomaterials is complicated and it needs a combination of a series of unit operations including mixing of the reactants,critical nuclei, growth of particles, separation, and drying.Therefore, the development of scale-up synthesis methods is becoming important for translational applications.Many previous studies have focused on the reactions in autoclave reactors and the influence of the molar ratio of reactants, solvent types, surfactants, reaction temperature, reaction time, and other related factors.On the other side, it is also important to consider what types of reactors might be used to achieve the preparation of rare-earth luminescent nanomaterials in high quality and large scale.