Live-cell superresolution pathology reveals different molecular mechanisms of pelizaeus-merzbacher disease

• 来源期刊: 科学通报（英文版）
• 年，卷（期）: 2020,（24）
• 所属期刊栏目: SHORT COMMUNICATIONS
• 页码范围: 2061-2064
• 页数: 4页
• 语种: 英文

摘要

Modern cellular pathology relies on conventional microscopes to study the etiology and pathogenesis of diseases,which suffer from limited spatial resolution,little dynamic information due to sample fixation,and the lack of molecular information.For exam-ple,Pelizaeus-Merzbacher disease(PMD)is a genetic disorder of the central nervous system caused by different duplications or mutations of the proteolipid protein 1 gene(PLP1)in oligodendro-cytes,which leads to hypomyelination and leukodystrophy in patients classified into either classical,transitional,or connatal phenotype[1].However,the correlations between genotypes and phenotypes at cellular level remain elusive.