Blood-retinal barrier as a converging pivot in understanding the initiation and development of retinal diseases

• 作者: Fan Zhi-Gang Yang Xue Yu Xiao-Wei Zhang Dan-Dan
• 来源期刊: 中华医学杂志英文版
• 关键词: Blood-retinal barrier Retinal inflammatory diseases Age-related macular degeneration Diabetic retinopathy Primary open-angle glaucoma Neuroinflammation
• 年，卷（期）: 2020,（21）
• 所属期刊栏目: Review Article
• 页码范围: 2586-2594
• 页数: 9页
• 语种: 中文
• DOI: 10.1097/CM9.0000000000001015

摘要

Clinical ophthalmologists consider each retinal disease as a completely unique entity. However, various retinal diseases, such as uveitis, age-related macular degeneration, diabetic retinopathy, and primary open-angle glaucoma, share a number of common pathogenetic pathways. Whether a retinal disease initiates from direct injury to the blood-retinal barrier (BRB) or a defect/injury to retinal neurons or glia that impairs the BRB secondarily, the BRB is a pivotal point in determining the prognosis as self-limiting and recovering, or developing and progressing to a clinical phenotype. The present review summarizes our current knowledge on the physiology and cellular and molecular pathology of the BRB, which underlies its pivotal role in the initiation and development of common retinal diseases.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Yang Xue		1	0	0.0	0.0
2	Yu Xiao-Wei		1	0	0.0	0.0
3	Zhang Dan-Dan		1	0	0.0	0.0
4	Fan Zhi-Gang		1	0	0.0	0.0