Progress of antibiotic-loaded bone cement in joint arthroplasty

• 作者: Feng Bin Peng Hui-Ming Weng Xi-Sheng Xu Yi-Ming
• 来源期刊: 中华医学杂志英文版
• 关键词: Polymethyl methacrylate Bone cement Antibiotic Modification
• 年，卷（期）: 2020,（20）
• 所属期刊栏目: Review Article
• 页码范围: 2486-2494
• 页数: 9页
• 语种: 中文
• DOI: 10.1097/CM9.0000000000001093

摘要

Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into clinical practice. Recent studies have revealed the limitations of the antibacterial effect of ALBC. Moreover, with the increase in high infection risk patients and highly resistant microbes, more researches and modification of ALBC are required. This paper reviewed latest findings about ALBC for most popular and destructive pathogens, summarized the influence of antibiotic kind, drug dosage, application method, and environment towards characteristic of ALBC. Subsequently, new cement additives and clinical applications of ALBC in joint arthroplasty were also discussed.