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摘要:
Heart Failure(HF)in elderly patients is a systemic syndrome where advanced age,comorbidities with organ system deterioration,frailty and impaired cognition significantly impact outcome.Cardiac cachexia,sarcopenia and frailty despite overlap in definitions are different clinical entities that frequently coexist in HF patients.However,these co-factors often remain unaddressed,resulting in poor quality-of-life,prolonged physical disability and exercise intolerance and finally with higher rehospitalization rates and mortality.Strategy aim to increase muscle mass and muscle strength and delay the occurrence of frailty state appear essential in this regard.Common HF drugs therapy(b-blockers,angiotensinconverting enzyme inhibitors)and prescription of physical exercise program remain the cornerstone of therapeutic approach in HF patients with new promising data regarding nutritional supplementation.However,the treatment of all these conditions still remain debated and only a profound knowledge of the specific mechanisms and patterns of disease progression will allow to use the appropriate therapy in a given clinical setting.For all these reasons we briefly review current knowledge on frailty,sarcopenia and cachexia in HF patients with the attempt to define clinically significant degrees of multiorgan dysfunction,specific"red alert"thresholds in clinical practice and therapeutic approach.
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篇名 Frailty,sarcopenia and cachexia in heart failure patients:Different clinical entities of the same painting
来源期刊 世界心脏病学杂志:英文版(电子版) 学科 医学
关键词 Heart failure SARCOPENIA CACHEXIA FRAILTY Terapheutic implication COMORBIDITIES
年,卷(期) 2021,(1) 所属期刊栏目
研究方向 页码范围 1-10
页数 10页 分类号 R73
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Heart
failure
SARCOPENIA
CACHEXIA
FRAILTY
Terapheutic
implication
COMORBIDITIES
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研究分支
研究去脉
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期刊影响力
世界心脏病学杂志:英文版(电子版)
月刊
1949-8462
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
78
总下载数(次)
1
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0
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