Multiple myeloma(MM)is a heterogeneous disease of the hematological system,characterized by different subtypes and different prognosis.Age,tumor burden,biological characteristics and treatment response can affect the prognosis.MM cells accumulate in bone marrow and produce abnormal immunoglobulin.Abnormal immunoglobulin does not participate in immune response and inhibits adaptive immune system is the most significant pathophysiological characteristics of MM.Hyperviscosity,amyloidosis,infection and kidney injury are the important complications of MM.This paper analyzes the traditional Chinese medicine(TCM)understanding of these important complications,and summarizes the commonly used clinical Chinese medicine,in order to provide important basis for the TCM treatment of multiple myeloma.