Genetic variants associated with endometriosis patients:a systematic review

• 作者: Bo Hu Xin jin Guang-Tao Xu Ping Qian Long Xu Li-Min Jin De-Qing Chen
• 来源期刊: 精准医学研究
• 学科: 医学
• 关键词: ENDOMETRIOSIS Genetic variants Single nucleotide polymorphism
• 年，卷（期）: 2021,（1）
• 页码范围: 7-20
• 页数: 14页
• 分类号: R73

摘要

Endometriosis is defined as the presence of endometrium-like tissue outside the uterus,80%of which occur in the ovaries.It is characterized by an estrogen-dependent produces periodic and repeated bleeding,and may be accompanied by clinical symptoms such as dysmenorrhea,fatigue,dysuria,deep dyspareunia,and infertility.Due to the complex etiology and the yet-unknown pathogenesis of endometriosis,and the treatment effect is not ideal,causing significant physical and mental harm to reproductive-age women;thus,it has become a hot research topic.Endometriosis is still a mysterious disease of unknown origin and pathogenesis.Genetic factors are known to affect the manifestation and progression of endometriosis.A selection of genetic studies revealed genetic mutations and polymorphisms of endometriosis and their effects on the risk of developing this disease.This paper aimed to discuss the genetic variants associated with the risk of endometriosis and provided information to enrich the gene spectrum of endometriosis.