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摘要:
N-acetylcysteine(NAC)is an abundantly available antioxidant with a wide range of antidotal properties currently best studied for its use in treating acetaminophen overdose.It has a robustly established safety profile with easily tolerated side effects and presents the Food and Drug Administration's approval for use in treating acetaminophen overdose patients.It has been proven efficacious in offlabel uses,such as in respiratory diseases,heart disease,cancer,human immunodeficiency virus infection,and seasonal influenza.Clinical trials have recently shown that NAC's capacity to replenish glutathione stores may significantly improve coronavirus disease 2019(COVID-19)outcomes,especially in high risk individuals.Interestingly,individuals with glucose 6-phosphate dehydrogenase deficiency have been shown to experience even greater benefit.The same study has concluded that NAC's ability to mitigate the impact of the cytokine storm and prevent elevation of liver enzymes,C-reactive protein,and ferritin is associated with higher success rates weaning from the ventilator and return to normal function in COVID-19 patients.Considering the background knowledge of biochemistry,current uses of NAC in clinical practice,and newly acquired evidence on its potential efficacy against COVID-19,it is worthwhile to investigate further whether this agent can be used as a treatment or adjuvant for COVID-19.
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篇名 Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19
来源期刊 世界病毒学杂志 学科 医学
关键词 N-ACETYLCYSTEINE ANTIOXIDANT COVID-19 SARS-CoV-2 TREATMENT
年,卷(期) 2021,(2) 所属期刊栏目
研究方向 页码范围 34-52
页数 19页 分类号 R73
字数 语种
DOI
五维指标
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研究主题发展历程
节点文献
N-ACETYLCYSTEINE
ANTIOXIDANT
COVID-19
SARS-CoV-2
TREATMENT
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界病毒学杂志
不定期
2220-3249
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
124
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0
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