Synthesis, Characterization and Biological Activities of Binuclear Metal Complexes of 2-Benzoylpyridine and Phenyl(Pyridin-2-yl) Methanediol Derived from 1-Phenyl-1-(Pyridin-2-yl)-N-(Pyrimidin-2-yl) Methanimine Dihydrate Schiff Base

• 作者: Francis A. Ngounoue Kamga Evans Ngandung Mainsah Maurice Kuate Peter T. Ndifon
• 来源期刊: 无机化学期刊(英文)
• 学科: 化学
• 关键词: Binuclear Complexes Schiff Base 2-Benzoylpyridine Crystal Structure Antimicrobial Activity Antioxidant Activity
• 年，卷（期）: 2021,（1）
• 页码范围: 20-42
• 页数: 23页
• 分类号: O62

摘要

The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using ¹³C-NMR, ¹H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L₁) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L₁ to give binuclear metal complexes of 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L₁) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L₂) and phenyl(pyridin-2-yl)methanediol (L₃) from the hydrolysis of L₁. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). <i>In vitro</i> antibacterial and antifungal activity against three bacterial strains (<i>Escherichia coli, Klebsiella pneumoniae</i> and <i>Staphylococcus aureus</i>) and three fungal stains (<i>Candida albicans, Candida glabrata and Candida parapsilosis</i>) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.