Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

• 作者: Yifan Chen Xuejing Shao Ji Cao Hong Zhu Bo Yang Qiaojun He Meidan Ying
• 来源期刊: 药学学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Reviews
• 页码范围: 309-321
• 页数: 13页
• 语种: 英文

摘要

Cullin-RING ligases(CRLs)recognize and interact with substrates for ubiquitination and degradation,and can be targeted for disease treatment when the abnormal expression of substrates in-volves pathologic processes.Phosphorylation,either of substrates or receptors of CRLs,can alter their interaction.Phosphorylation-dependent ubiquitination and proteasome degradation influence various cellular processes and can contribute to the occurrence of various diseases,most often tumorigenesis.These processes have the potential to be used for tumor intervention through the regulation of the activ-ities of related kinases,along with the regulation of the stability of specific oncoproteins and tumor suppressors.This review describes the mechanisms and biological functions of crosstalk between phos-phorylation and ubiquitination,and most importantly its influence on tumorigenesis,to provide new di-rections and strategies for tumor therapy.