Testing the leanocentric locking-point theory by in silico partial lipectomy

• 作者: Guanyu Wang
• 来源期刊: 定量生物学（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: RESEARCH ARTICLES
• 页码范围: 73-83
• 页数: 11页
• 语种: 英文

摘要

Background:The lipostatic set-point theory,ascribing fat mass homeostasis to leptin mediated central feedback regulation targeting the body's fat storage,has caused a variety of conundrums.We recently proposed a leanocentric locking-point theory and the corresponding mathematical model,which not only resolve these conundrums but also provide valuable insights into weight control and health assessment.This paper aims to further test the leanocentric theory.Methods:Partial lipectomy is a touchstone to test both the leanocentric and lipostatic theories.Here we perform in silico lipectomy by using a mathematical model embodying the leanocentric theory to simulate the long-term body fat change after removing some fat cells in the body.Results:The mathematical modeling uncovers a phenomenon called post-surgical fat loss,which was well-documented in real partial lipectomy surgeries;thus,the phenomenon can serve as an empirical support to the leanocentric theory.On the other hand,the leanocentric theory,but not the lipostatic theory,can well explain the post-surgical fat loss.Conclusions:The leanocentric locking-point theory is a promising theory and deserves further testing.Partial lipectomy surgeries are beneficial to obese patients for quite a long period.