Relationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes

• 作者: Cheng-Xia Kan En-Wen Mao Fang Han Hong-XiSun Na Huang Ning-Ning Hou Xiao-Dong Sun Yong-Ping Liu Yu-Ting Ma
• 来源期刊: 世界糖尿病杂志:英文版(电子版)
• 学科: 医学
• 关键词: DICKKOPF-1 ALBUMINURIA Diabetic kidney disease Type 2 diabetic mellitus WINGLESS MICROALBUMINURIA
• 年，卷（期）: 2021,（1）
• 页码范围: 47-55
• 页数: 9页
• 分类号: R58

摘要

BACKGROUND Diabetic kidney disease is a microvascular complication of diabetes with complex pathogenesis.Wingless signaling-mediated renal fibrosis is associated with diabetic kidney disease.Dickkopf-1,a negative regulator of Wingless,has been proven to participate in renal fibrosis,glucose metabolism,and inflammation.However,whether serum Dickkopf-1 levels are associated with diabetic kidney disease remains unclear.AIM To assess the relationship between serum Dickkopf-1 levels and albuminuria in individuals with type 2 diabetes.METHODS Seventy-three type 2 diabetes patients and 24 healthy individuals were enrolled in this case-control study.Diabetic individuals were separated into normal albuminuria,microalbuminuria,and macroalbuminuria groups based on their urinary albumin/creatinine ratios(UACRs).Clinical characteristics and metabolic indices were recorded.Serum Dickkopf-1 levels were determined by enzymelinked immunosorbent assay.RESULTS No significant difference in serum Dickkopf-1 levels was found between healthy individuals and the normal albuminuria group.However,the levels in the microalbuminuria group were significantly lower than those in the normal albuminuria group(P=0.017),and those in the macroalbuminuria group were the lowest.Bivariate analysis revealed that serum Dickkopf-1 levels were positively correlated with hemoglobin A1c level(r=0.368,P<0.01)and estimated glomerular filtration rate(r=0.339,P<0.01),but negatively correlated with diabetes duration(r=-0.231,P=0.050),systolic blood pressure(r=-0.369,P=0.001),serum creatinine level(r=-0.325,P<0.01),and UACR(r=-0.459,P<0.01).Multiple and logistic regression showed that serum Dickkopf-1 levels were independently associated with UACR(odds ratio=0.627,P=0.021).CONCLUSION Serum Dickkopf-1 levels are negatively associated with UACR.Lower serum Dickkopf-1 levels could be a critical risk factor for albuminuria in diabetes.