Anti-Obesity and Anti-Hyperlipidemia Effects of Antrodia cinnamomea Mycelial Extract in High-Fructose Diet-Fed Mice

• 作者: LI Jinshan WANG Zhuo LIU Yanayang DING Yueyue MEI Zewen MEI Yuxia LIANG Yunxiang
• 来源期刊: 武汉大学自然科学学报（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Biomedicine
• 页码范围: 39-47
• 页数: 9页
• 分类号: TP305
• 语种: 英文
• DOI: 10.19823/j.cnki.1007-1202.2021.0004

摘要

This study investigated hypolipidemic,weight-reducing,and hepatoprotective effects of Antrodia cinnamomea mycelial ex-tract obtained from solid-state culture(ACME)in an HFrD-induced obese/hyperlipidemic mouse model.Following 4-week ACME treatment,body weight,epididymal fat index,and some serum bio-chemical indices were measured.Expression levels of some related genes involved in cholesterol and lipid metabolism were analyzed by qRT-PCR.Moreover,histological studies of hepatic tissues were also conducted.After ACME treatment,body weight and epididymal fat index were significantly lower than that in model control group.ACME and simvastatin significantly reduced serum total cholesterol(T-CHO)and low-density lipoprotein cholesterol(LDL-C)levels,and increased high-density lipoprotein cholesterol(HDL-C)level.Subsequent experiments showed that:(i)ACME regulated transcrip-tional expression of 3-hydroxy-3-methylglutaryl-CoA reductase(HMGR),low-density lipoprotein receptor(LDLR),adipose triglyc-eride lipase(ATGL),and fatty acid synthase(FAS),with consequent reduction of blood lipid levels and body weight;(ii)ACME en-hanced total antioxidant capacity(T-AOC)and superoxide dismu-tase(SOD)activity in hepatic tissues;(iii)ACME reduced malondialdehyde(MDA)level and ameliorated lipid oxidative damage in liver.Our findings indicate that ACME is a strong candi-date for development as a novel anti-hyperlipidemia and anti-obesity health product.