Effect of preoperative nutrition therapy type and duration on short-time outcomes in gastric cancer patient with gastric outlet obstruction

• 作者: Jiyang Li Shaoqing Li Hongqing Xi Peifa Liu Wenquan Liang Yunhe Gao Chuang Wang Bo Wei Lin Chen Yun Tang Zhi Qiao
• 来源期刊: 中国癌症研究（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Original Article
• 页码范围: 232-242
• 页数: 11页
• 语种: 英文
• DOI: 10.21147/j.issn.1000-9604.2021.02.10

摘要

Objective: To avoid perioperative complications caused malnutrition,nutrition therapy is necessary in gastric outlet obstruction (GOO) patients.Compared to parenteral nutrition (PN),enteral nutrition (EN) is associated with many advantages.This study aimed to investigate whether preoperative EN has beneficial clinical effects compared to preoperative PN in gastric cancer patients with GOO undergoing surgery.Methods: According to the methods of preoperative nutrition therapy,143 patients were divided into EN group (n=42) and PN group (n=101) between January 2013 and December 2017 at the Chinese People's Liberation Army General Hospital.Multiple logistic regression models were used to assess the association between the methods of preoperative nutrition therapy and postoperative day of flatus passage.The generalized additive model and two-piecewise linear regression model were used to calculate the inflection point of the preoperative nutritional therapy time on the postoperative day of flatus passage in the PN group.Results: EN shortened the postoperative day of flatus passage in gastric cancer patients with GOO,which is a protective factor,especially in patients who underwent non-radical operations and the postoperative day of flatus passage reduced when the preoperative PN therapy was up to 3 d and a longer PN therapy (＞3 d) did not accelerate the postoperative recovery of gastrointestinal functions.Conclusions: Preoperative EN therapy would benefit gastric cancer patients with GOO by accelerating postoperative recovery.For patients with absolute obstruction,no more than 3-day PN therapy is recommended if patients can tolerate general anesthesia and surgery.