Let (sb~) be the extended Schr(o)dinger-Virasoro Lie algebra and n ≥ 1 an integer.A map f: (sb~)n =(sb~) × (sb~) × … × (sb~) → (sb~) is called an n-derivation if it is a derivation inone variable while other variables fixed.We investigate n-derivations of the extendedSchr(o)dinger-Virasoro Lie algebra (sb~).The main result when n =2 is then applied tocharacterize the linear commuting maps and the commutative post-Lie algebra structureson (sb~).