Preliminary Exploration of the Initial Diagnostic Prediction Model of Moderate Coronavirus Disease 2019 (2019-nCoV) Based on Clinical Data

• 作者: Ritian Zha Jingmin Gui Jiancheng Hao Yungui Zhou Wensheng Jiang Shangming Chen Jiajia Zhao Ruiping Xuan Zhendong Jiang Xiaoqin Liu Ping Wang Lei Zhang
• 来源期刊: 护理学期刊(英文)
• 学科: 医学
• 关键词: Clinical Data 2019-nCoV Prediction Model
• 年，卷（期）: 2021,（1）
• 页码范围: 7-16
• 页数: 10页
• 分类号: R73

摘要

<strong>Objective: </strong>To explore those differences and relationships of the initial diagnostic clinical data between confirmed cases of 2019-nCoV and suspected cases of COVID-19, and then to establish prediction models for predicting the probability of the first diagnosis of 2019-nCoV. <strong>Methods:</strong> A total of 81 suspected cases and 87 confirmed cases of moderate 2019-nCoV diagnosed initially in the isolation wards of the First People’s Hospital of Wuhu and the People’s Hospital of Wuwei and Wuhan Caidian Module Hospital with the help of our hospital doctors were gathered, and retrospectively analyzed. <strong>Results:</strong> The most common symptoms were fever (76.79%) and cough (64.29%) in the total of 168 cases. The median age was 45 (35 - 56) years old in the 87 confirmed cases of moderate 2019-nCoV, older than the median age 36 (29 - 50) in the 81 suspected cases. There were significant more in the former than in the latter in the incidence of myalgia, ground-glass opacity (GGO), invasions of lesion in the peripheral lobes, vascular thickening and bronchial wall thickening, interlobular septal thicking, and small pulmonary nodules. On the contrary, there were less in the former than in the latter in the total number of leukocytes and neutrophils in blood routine examination and the levels of procalcitonin (PCT). Two groups were statistically significantly different (<em>P</em> < 0.05). Multivariate logistic regression analysis showed that age, fever, myalgia, GGO, vascular thickening and bronchial wall thickening, invasions of lesion in the peripheral lobes were independent factors for identification of 2019-nCoV, and the total number of leukocytes, cough, pharyngalgia and headache were negatively related. The established mathematical equation for predicting model for predicting the probability of the first diagnosis of 2019-nCoV is: <em>P</em> = e^<em>x</em>/(1 + e^<em>x</em>), <em>x</em> = <span style="white-space:nowrap;">&minus;</span>6.226 + (0.071 × ages) +