Characterization and DNA Interaction of Lanthanide Complexes Based on Thiourea Ligand

• 作者: REN Ya-Wen HU Hang-Na ZHANG Jun ZHUANG Xin-Jing LI Dong-Ping LI Yong-Xiu
• 来源期刊: 结构化学
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: coordination cbemistry
• 页码范围: 47-54
• 页数: 8页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-2760

摘要

Three isostructural lanthanide complexes,namely[Ln(L)3·CH3OH](Ln = Tb(1),Dy(2),Ho(3),HL= N-(pyridin-2-ylcarbamothioyl)benzamide),were successfully synthesized and characterized by IR,UV,elemental analysis,single-crystal X-ray diffraction and DNA-biding analysis.X-ray single-crystal diffractions show that the family of lanthanide complexes crystallizes in monoclinic C2/c space group.Each lanthanide atom is coordinated with three carbonyl-O atoms,three pyridyl-N atoms and three imine-N atoms from three distinct L-1 ligands,forming a distorted tricapped trigonal prism.The binding properties of complexes with ct-DNA were studied by simulating the physiological environment of human body.The results suggest that compounds could bind with ct-DNA through interaction under a spontaneous process.