The effect of sodium hydrogen carbonate (NaHCO3) on human sperm adenylyl cyclase activity

• 作者: Ali Ahmadi
• 来源期刊: 精准医学研究
• 学科: 经济
• 关键词: CARBONATE EFFECT enable
• 年，卷（期）: 2021,（1）
• 页码范围: 45-46
• 页数: 2页
• 分类号: F42

摘要

Sperm fertility and motility requires the presence of a functional flagellum to act as a motor to enable sperms to move in fluids.Cyclic adenosine monophosphate(cAMP),as a regulator of many biological pathways,contributes in mammalian sperms to the production of soluble adenyl cyclase,a process which is regulated through Ca2+and HCO3-dependent mechanisms and triggers widespread physiological alterations essential to sperm viability.The aim of this study was to investigate the effect of sodium hydrogen carbonate(NaHCO3)on human sperm adenylyl cyclase activity.Studies show that flagellum is essential for sperms to keep their motility.Furthermore,multiple cellular and molecular players and pathways(i.e.,capacitance)are critical for normal maturation of sperms in final stages[1].Sperm capacity is an incorrect maturation process observed in the female reproductive system or can be tested in specific environments,the end point of which has been shown to allow the sperm to withstand the acrosome reaction and fertilize the egg.Interactions between membrane components(e.g.,ion channels)and intracellular skeletal proteins are strictly regulated and are important for promoting these signaling pathways.