Predictive Value of Dynamic Peri-Transplantation MRD Assessed By MFC Either Alone or in Combination with Other Variables for Outcomes of Patients with T-Cell Acute Lymphoblastic Leukemia

• 作者: Zhi-dong WANG Yue-wen WANG Lan-ping XU Xiao-hui ZHANG Yu WANG Huan CHEN Yu-hong CHEN Feng-rong WANG Wei HAN Yu-qian SUN Chen-hua YAN Fei-fei TANG Xiao-dong MO Ya-zhe WANG Yan-rong LIU Kai-yan LIU Xiao-jun HUANG Ying-jun CHANG
• 来源期刊: 当代医学科学（英文）
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: HEMATOLOGY COLUMN
• 页码范围: 443-453
• 页数: 11页
• 语种: 英文
• DOI: 10.1007/s11596-021-2390-6

摘要

We performed a retrospective analysis to investigate dynamic peri-hematopoietic stem cell transplantation(HSCT)minimal/measurable residual disease(MRD)on outcomes in patients with T-cell acute lymphoblastic leukemia(T-ALL).A total of 271 patients were enrolled and classified into three groups:unchanged negative MRD pre-and post-HSCT group(group A),post-MRD non-increase group(group B),and post-MRD increase group(group C).The patients in group B and group C experienced a higher cumulative incidence of relapse(CIR)(42％vs.71％vs.16％,P＜0.001)and lower leukemia-free survival(LFS)(46％vs.21％vs.70％,P＜0.00l)and overall survival(OS)(50％vs.28％vs.72％,P＜0.001)than in group A,but there was no significant difference in non-relapse mortality(NRM)among three groups(14％vs.12％vs.8％,P=0.752).Multivariate analysis showed that dynamic peri-HSCT MRD was associated with CIR(HR=2.392,95％CI,1.816-3.151,P＜0.001),LFS(HR=1.964,95％CI,1.546-2.496,P＜0.001)and OS(HR=1.731,95％Cl,1.348-2.222,P＜0.001).We also established a risk scoring system based on dynamic peri-HSCT MRD combined with remission status pre-HSCT and onset of chronic graft-versus-host disease(GVHD).This risk scoring system could better distinguish CIR(c=0.730)than that for pre-HSCT MRD(c=0.562),post-HSCT MRD(c=0.616)and pre-and post-MRD dynamics(c=0.648).Our results confirm the outcome predictive value of dynamic peri-HSCT MRD either alone or in combination with other variables for patients with T-ALL.