Genome engineering technologies in rabbits

• 作者: Jun Song Jifeng Zhang Jie Xu Minerva Garcia-Barrio Y.Eugene Chen Dongshan Yang
• 来源期刊: 生物医学研究杂志（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: REVIEW ARTICLES
• 页码范围: 135-147
• 页数: 13页
• 分类号: Q789
• 语种: 英文

摘要

The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates.However,the technology for precise genome manipulations in rabbit has been stalled for decades,severely limiting its applications in biomedical research.Novel genome editing technologies,especially CRISPR/Cas9,have remarkably enhanced precise genome manipulation in rabbits,and shown their superiority and promise for generating rabbit models of human genetic diseases.In this review,we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits.