Senescent bone marrow microenvironment promotes Nras-mutant leukemia

• 作者: Peiqing Zhou Chengxiang Xia Tongjie Wang Yong Dong Qitong Weng Xiaofei Liu Yang Geng Jinyong Wang Juan Du
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Letter to the Editor
• 页码范围: 72-74
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa062

摘要

Dear Editor, In recent years,there is growing inter-est regarding the roles of senescent bone marrow (BM) microenvironment in the initiation of leukemia.Aged mice transplanted with AML1-ETO (AML1-ETO fusion protein)-positive hematopoietic stem cells (HSCs) present with a signifi-cant increase in the frequency of AML-ETO-positive early progenitor cells in BM as well as an increase of immature mye-loid cells compared to young recipients(Vas et al.,2012).