Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis

• 来源期刊: 骨研究（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 75-85
• 页数: 11页
• 语种: 英文

摘要

INTRODUCTION Osteoblasts (OBs) are formed by mesenchymal stem cells (MSCs) originating from the neural ectoderm and paraxial and lateral plate mesoderm.1 Neural ectoderm-originating OBs are formed directly from condensed mesenchyme tissue without going through the intermediate stages. Such OBs generate most of the cranial squamous bones and the lateral part of the clavicle. The remainder of the skeleton is generated by OBs from the paraxial and lateral plate mesoderm and is first formed of an intermediate cartilaginous analog.