<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> The bispectral index (BIS) derived from the electroencephalogram is an additional means of monitoring the depth of narcosis.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:Verdana;"> To compare the monitoring of the depth of narcosis by the BIS associated with clinical data versus standard monitoring at the University Hospital of Parakou in Benin in 2019.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was an observational study for descriptive and analytical purposes with prospective data collection, carried out in general surgery and intensive care unit for 4 months. The inclusion criteria were: an age ≥ 18 years, an ASA score ≤ 3, surgery under general anesthesia and informed consent of the patient. Two groups were formed: non-BIS group monitored by clinical parameters (PA, FC, FR, EtCO</span><sub><span style="font-family:Verdana;vertical-align:sub;">2</span></sub><span style="font-family:Verdana;">, and SpO</span><sub><span style="font-family:Verdana;vertical-align:sub;">2</span></sub><span style="font-family:Verdana;">) only and BIS group monitored by bispectral index in addition to clinical parameters. Patients were seen 48 hours after the procedure.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results:</span></b><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">36 patients were collected. The mean age was 40.63 ± 16.77 years with a sex ratio of 3. ASA 1 patients represented 86.11% of the sample and ASA2 patients 13.89%. The average doses of Propofol were not significantly reduced in the BIS group (p = 0.555). On the other hand, the period of intraoperative recovery (p-value = 0.007) and the NVPO (p = 0.043;OR = 0.10;95% CI [0.01 - 0.97]) were signifi