Psychosis and Dandy-Walker syndrome:a case report and review of the literature

• 作者: Alejandro Porras Segovia Margarita Guerrero-Jiménez Carmen Maura Carrillo de Albornoz Calahorro Luis Gutierrez-Rojas
• 来源期刊: 综合精神医学
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Case reports
• 页码范围: 111-115
• 页数: 5页
• 语种: 中文
• DOI: 10.1136/gpsych-2020-100254

摘要

Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms.We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis.A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions,auditory hallucinations and violent behaviour.The MRI performed showed the typical alterations of Dandy-Walker variant:vermian hypoplasia and cystic dilatation of the fourth ventricle.He also suffered from mild intellectual disability.After being treated with olanzapine 10 mg/d for a month,his psychotic symptoms greatly improved and he was discharged.In conclusion,DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal,thalamic and cerebellar areas.The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia.