This paper is devoted to the construction of one and two-weight Z2R2 additive codes, where R2 =F2[v]/<v4>. It is a generalization towards another direction of Z2Z4 codes (S.T. Dougherty, H.W. Liu and L. Yu,"One weight Z2Z4 additive codes", Applicable Algebra in Engineering, Communication and Computing, Vol.27, No.2, pp.123–138, 2016). A MacWilliams identity which connects the weight enumerator of an additive code over Z2 R2 and its dual is established. Several construction methods of one-weight and two-weight additive codes over Z2 R2 are presented. Several examples are presented to illustrate our main results and some open problems are also proposed.