A Comparison of One Hour versus Two-Hour Postprandial Glycemic Control during Pregnancy: A Prospective Cohort Study Carried out at Antenatal Ward Teaching Hospital Peradeniya, Sri Lanka

• 作者: W. M. M. P. B. Wanasinghe R. M. C. J. Ratnayake
• 来源期刊: 生殖科学(英文)
• 学科: 医学
• 关键词: GESTATIONAL Diabetes Fetal Macrosomia PRE-ECLAMPSIA
• 年，卷（期）: 2021,（1）
• 页码范围: 69-80
• 页数: 12页
• 分类号: R58

摘要

<strong>Background</strong> It is well known that both pre-excising and gestational diabetes mellitus in pregnancy is associated with multiple maternal and fetal complications. There are various guidelines developed to reduce these complications, yet there is no universal agreement regarding the ideal management. For those with pre-exciting or gestational diabetes mellitus, the control of blood sugar is assessed either with 1st-hour post-prandial blood sugar values or with the 2nd-hour post-prandial blood sugar values. <strong>Objective </strong>To compare the long-term blood glucose control (HbA1c values) of pregnant women by utilizing results of 1-hour postprandial blood sugar values against 2-hour post-prandial blood sugar values, in the antenatal ward at the professorial unit, Teaching Hospital Peradeniya. <strong>Materials and Methods</strong> A prospective cohort study was carried out among 138 pregnant women with diabetes mellitus, who were managed in two different clinics at the professorial unit, Teaching Hospital Peradeniya. The blood glucose control in group 1 (n = 69) was assessed and optimized with 1st-hour postprandial blood sugar values and group 2 (n = 69) was evaluated with 2nd-hour postprandial values throughout the pregnancies. Following delivery, all subjects were reassessed with blood HbA1c and analyzed with the independent t-test. Feto-maternal complications were analyzed and evaluated using descriptive statistics and Chi-Square tests. <strong>Results</strong> Of the subjects, 97.1% were diagnosed with gestational diabetes mellitus. The mean value of HbA1c for group 1, managed with 1st-hour blood glucose values was 5.73 and 6.04 (p = 0.02) respectively for group 2. Fetal macrosomia was also significantly (p < 0.01) low in the 1-hour blood sugar control group.<strong> Conclusion</strong> Long-term control of blood sugar was significantly superior among the subjects managed with 1st-hour postprandial blood sugars with a statistically significant reduction in foetal macrosomia.