Enlightenment and Reference of Vaccine Clinical Trial Design Based on Immunological Surrogate Endpoints in the United States

• 作者: Gu Jinmeng Yang Yue Xing Hua
• 来源期刊: 亚洲社会药学
• 学科: 医学
• 关键词: VACCINE immunological surrogate endpoint adaptive design
• 年，卷（期）: 2021,（1）
• 页码范围: 68-75
• 页数: 8页
• 分类号: R73

摘要

Objectives To explore the optimization method of vaccine clinical trial design based on immunological surrogate endpoint to improve the quality and efficiency of vaccine clinical research and development.Methods As to the problems in the vaccine clinical research in China,the relevant guidelines and literatures of FDA and WHO were used to analyze and summarize the methods of optimizing the design of vaccine clinical trials.Results and Conclusion The adaptive design guidelines are established to guide clinical trial design,encourage the development and application of immunological surrogate endpoints,establish qualification process for drug development tools and information disclosure procedures to improve vaccine development efficiency.