Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients

• 作者: Lamyae Nouiakh Karima Oualla Imane Ouafki Soumia Berrad Hayat Erraichi Lamiae Amaadour Zineb Benbrahim Samia Arifi Nawfel Mellas
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: Tyrosine Kinase Inhibitors SAFETY Side Effects
• 年，卷（期）: azzlyw_2021,（3）
• 页码范围: 116-126
• 页数: 11页
• 分类号: R73

摘要

Tyrosine kinase inhibitors (TKIs) have become a prominent option in the therapeutic arsenal of several cancers. The safety of these drugs has shown various toxicities with varying frequency and severity between different agents. </span><span>The aim of this study is</span><span> to describe the safety profile of different classes of TKI used in various solid tumors. It is a retrospective</span></span></span><span><span><span>ly</span></span></span><span><span><span><span> descriptive study conducted in the Department of Medical Oncology at Hassan II University Hospital of Fez, Morocco, </span><span>over a period of</span><span> 6 years from April 2013 until April 2019. It included 216 patients who received one or more TKI for different indications in solid tumors.</span></span></span></span><span><span><span> </span></span></span><span><span><span>The average age in our series was 61.4 years with a sex ratio F/M of 1.07. Among the most used TKIs in our department</span></span></span><span><span><span> </span></span></span><span><span><span>according to their availability: Imatinib (32%) and sunitinib (32%). All patients received one or more tyrosine kinase inhibitors according to the indication. Kidney cancer was the most common malignancy (36%), followed by gastrointestinal stromal tumors (33%). The median duration of treatment was 15 months with extremes of 1 month and 102 months. The main side effects were: Cutaneous in 43% of patients. Digestive toxicity occurred in 36% of cases.</span></span></span><span><span><span> </span></span></span><span><span><span><span>Hematotoxicity was reported in 33% of cases. The safety profile of TKIs used in our study was comparable to their global tolerance reported in </span><span>literature</span><span>. More studies are needed to investigate the relationship between their toxicity and their efficacy in </span><span>Moroccan</span><span> population.