Current knowledge of Krüppel-like factor 5 and vascular remodeling:providing insights for therapeutic strategies

• 作者: Ziyan Xie Junye Chen Chenyu Wang Jiahao Zhang Yanxiang Wu Xiaowei Yan
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Review
• 页码范围: 79-90
• 页数: 12页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa080

摘要

Vascular remodeling is a pathological basis of various disorders.Therefore,it is necessary to understand the occurrence,prevention,and treatment of vascular remodeling.Krüppel-like factor 5 (KLF5) has been identified as a significant factor in cardio-vascular diseases during the last two decades.This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications.KLF5 modulates numerous biological processes,which play essential parts in the development of vascular remodeling,such as cell proliferation,phenotype switch,extracellular matrix deposition,inflammation,and angiogenesis by altering downstream genes and signaling pathways.Considering its essential functions,KLF5 could be developed as a potent therapeutic target in vascular disorders.