Association between SLC17A7 gene polymorphisms and venlafaxine for major depressive disorder in a Chinese Han population: a prospective pharmacogenetic case-control study

• 作者: Liu Liangjie Ren Decheng Yuan Fan Bi Yan Guo Zhenming Ma Gaini Xu Fei Hou Binyin Ji Lei Chen Zhixuan An Lin Zhang Naixin Yu Tao Li Xingwang Yang Fengping Sun Xueli Dong Zaiquan Yu Shunying Yi Zhenghui Xu Yifeng He Lin Wu Shaochang Zhao Longyou Cai Changqun He Guang Shi Yi
• 来源期刊: 生物组学研究杂志（英文）
• 关键词: association study major depression pharmacogenomics SLC17A7 gene venlafaxine treatment
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Research Article
• 页码范围: 124-129
• 页数: 6页
• 语种: 中文
• DOI: 10.1097/JBR.0000000000000096

摘要

Objective::Venlafaxine is a common antidepressant and its therapeutic effect varies among people with different genetic backgrounds. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the SLC17A7 gene are associated with the treatment outcome of venlafaxine in a Chinese Han population with major depressive disorder. Methods::This prospective pharmacogenetic case-control study that involved genotyping of four SNPs of SLC17A7 was conducted on 175 major depressive disorder patients of Chinese Han origin, aged 18 to 65 years, participated in the study from April 2005 to September 2006. Comparisons of allele and genotype frequencies of all SNPs were performed between the responder/remission group and the nonresponder/nonremission group. This study was approved by the Institutional Ethics Committee of Sichuan University (approval No. 20151112-265). Results::The allele and genotype frequencies of the four candidate SNPs in SCL17A7 showed no significant difference between responders and nonresponders. Meanwhile, no significant difference was detected in the four investigated SLC17A7 SNPs between patients who did and did not exhibit remission. Although one of the investigated SLC17A7 variants (rs1578944) demonstrated a significant association ( P=0.022) with a response to venlafaxine after 6 weeks of treatment in the survival analysis, the association was unclear after a Bonferroni multiple comparisons test was conducted. Conclusion::No significant association exists between the four candidate SNPs (rs1043558, rs1320301, rs1578944, and rs74174284) in SLC17A7 and venlafaxine treatment in the Chinese Han population.