The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study

• 作者: Yan Yinkun Li Shengxu Liu Yang Bazzano Lydia He Jiang Mi Jie Chen Wei
• 来源期刊: 儿科学研究（英文）
• 关键词: Body mass index C-reactive protein Childhood Longitudinal study
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Original Article
• 页码范围: 21-27
• 页数: 7页
• 语种: 中文
• DOI: 10.1002/ped4.12248

摘要

Importance::The impact of long-term burden of excessive body weight, beginning in childhood, on inflammatory status in adulthood has been poorly described.Objective::To characterize the longitudinal body mass index (BMI) trajectory from childhood and examine its relationship with inflammatory status in adulthood.Methods::We included 1285 adults who had 4-15 repeat measurements of BMI from childhood to adulthood. The area under the curve (AUC) of growth curves was calculated to characterize long-term burden (total AUC) and trends (incremental AUC) of BMI.Results::After adjusting for covariates, higher values of BMI in terms of childhood and adulthood, as well as total and incremental AUC, were strongly associated with elevated levels of adult C-reactive protein (CRP) in the four race-sex groups. There were significant differences in linear and nonlinear curve parameters between the normal and high CRP groups for all race-sex groups ( P < 0.01). Compared with participants who had consistently low BMI in both childhood and adulthood, participants with high BMI in adulthood had higher CRP levels ( P < 0.001), irrespective of their childhood BMI status; participants with high BMI in childhood but low BMI in adulthood had similar adult CRP levels. Interpretation::The impact of excessive body weight on inflammation is cumulative and exacerbated over time. The influence of childhood overweight/obesity on inflammatory status in adulthood can be alleviated by reducing adiposity in adulthood.