Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health

• 作者: Abdul Ahad Aswathy Sebastian Aziz Ul-Rahman Bhushan M Jayarao Istvan Albert Levina Lim Masood Rabbani Muhammad Zubair Shabbir Murugan Subbiah Ruth Helmus Nissly Shubhada K.Chothe Suresh V.Kuchipudi
• 来源期刊: 亚太热带医药杂志（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Original Articles
• 页码范围: 64-72
• 页数: 9页
• 语种: 英文
• DOI: 10.4103/1995-7645.306762

摘要

Objective: To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1 (AOAV-1) isolates from poultry workers with respiratory symptoms. Methods: Using Illumina MiSeq, whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates. A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools. Results: Phylogenetic analysis and genetic distance estimation suggested a close relationship among human- and avian-originated velogenic strains of genotype ⅩⅢ, sub-genotype ⅩⅢ.2.1. Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains. Conclusions: To our knowledge, this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract. Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.