Broad-spectrum rescue compounds for structural p53 mutations:perspective on 'Arsenic trioxide rescues structural p53 mutations through a cryptic allosteric site'

• 作者: Jia-Le Wu Shuo Chen Min Lu
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Research Advance
• 页码范围: 155-157
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjab007

摘要

Precision medicine targeting gene mutations holds the promise of changing the landscape of cancer care and prog-nosis,but currently approved drugs in this category are efficacious in only a very small percentage of all cancer patients (Tannock and Hickman,2016).TP53,encoding the tumor suppressor and transcription factor p53,is the most frequently mutated gene in human can-cers (Joerger and Fersht,20116;Sabapathy and Lane,2018;Levine,20119).