Disease characteristics and neuropathological changes associated with cognitive dysfunction in obstructive sleep apnea

• 作者: Ji Tingting Li Xiaodan Qiu Yue Mei Lin Jia Xinbei Tai Jun Guo Yongli Zhang Jie Wang Shengcai Ni Xin
• 来源期刊: 儿科学研究（英文）
• 关键词: Obstructive sleep apnea Cognitive dysfunction Neuropathological mechanisms
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Review
• 页码范围: 52-57
• 页数: 6页
• 语种: 中文
• DOI: 10.1002/ped4.12247

摘要

Obstructive sleep apnea (OSA) is a common sleep-disordered breathing disease that often leads to many comorbidities (e.g., cognitive dysfunction), which adversely affect the quality of life for patients with OSA. Thus far, the underlying mechanisms of this dysfunction remain unclear. Many studies have focused on OSA-related characteristics, including intermittent hypoxemia and sleep fragmentation. There is increasing emphasis on neuroimaging studies to explore underlying relationships between neuropathological changes and cognitive dysfunction. This article reviews recent research progress concerning cognitive dysfunction associated with OSA to reveal potential mechanisms that contribute to this dysfunction.