Metabonomics: A Useful Tool to Reveal Underlying Relationships between Altered Chinese Medicine Syndromes and Ultrafiltration in Treatment of Heart Failure

• 作者: GUO Li-jun CHEN Ke-ji SUN Ming-qian WANG An-zhu GAO Feng ZHENG Yuan MA Xiao-chang
• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2021,（4）
• 所属期刊栏目: Original Articles
• 页码范围: 259-264
• 页数: 6页
• 语种: 英文
• DOI: 10.1007/s11655-020-3479-7

摘要

Objective: To reveal the underlying relationships between Chinese medicine (CM) syndromes and ultrafiltration (UF) in the treatment of heart failure based on a metabonomic approach.Methods: Seventeen acute decompensated heart failure (ADHF) patients were enrolled,and their CM syndromes before and after UF were collected.In addition,their venous plasma collected before and after UF was used for liquid chromatographmass spectrometer-based metabonomic analysis.Both reversed phase liquid chromatography and hydrophilic interaction liquid chromatography were used to analyze the plasma samples.Partial least-squares to latent structure-discriminant analyses were used for data analysis.Results: An obvious difference was observed preand post-treatment.A total of 17 potential biomarkers associating with alterd syndromes with UF including hypoxanthine,1-methylhistidine,phytosphingosine,O-decanoyI-R-carnitine,etc.were screened out,showing a significant change after UF.The major adjusted metabolic pathways were purine metabolism,histidine metabolism,leucine and isoleucine metabolism,arginine and proline metabolism,camitine shuttle,sphingolipid metabolism and phospholipid metabolism.Conclusions: Metabonomic approach is a useful tool to identify potential biomarkers of altered syndromes link to UF and could provide a theoretical basis for further research on the therapeutic mechanism of UF combined with CM.