Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy-a pilot longitudinal study

• 来源期刊: 生物医学研究杂志（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Pediatric Research
• 页码范围: 61-67
• 页数: 7页
• 分类号: R742.1
• 语种: 英文

摘要

To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy,a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA.Blood levels of calcium,phosphorus,alkaline phosphatase,and 25-hydroxy vitamin D [25(OH)D] and plasma VPA level were measured at 1- to 3-month intervals.At the initial and final measurements,vitamin D deficiency or insufficiency was recognized in 8 (32％) and 12 (42％),respectively.In girls,a decreasing trend in serum 25(OH)D levels (P＜0.05) was observed.Polytherapy had a significant negative effect on the longitudinal change of 25(OH)D (P＜0.05) in girls.In conclusion,our study indicates that a high proportion of girls after VPA therapy had hypovitaminosis D.