Research Progress on Human Endometrium Decidualization In vitro Cell Models

• 作者: Tang Zhi-Jing Guan Hai-Yun Wang Lu Zhang Wei
• 来源期刊: 生殖与发育医学（英文）
• 关键词: Cyclic Adenosine Monophosphate Decidualization Endometrium Estrogen In vitro Cell Model Progestogen
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Review Article
• 页码范围: 119-127
• 页数: 9页
• 语种: 中文
• DOI: 10.4103/2096-2924.320882

摘要

Decidualization is a special type of differentiation of endometrial stromal cells into secretory decidualized cells, which is closely related to the occurrence of menstruation and establishment of pregnancy. Decidualization abnormalities can cause female infertility and abortion, and the decidualization model in vitro is an important tool for studying relevant mechanisms. This article summarizes several in vitro decidualization models in recent research from three aspects, including the selection of model cells and culture systems, evaluation of decidualization markers, and induction schemes. These models can be appropriately selected and applied in specific endometrium-related disease models, such as endometriosis, recurrent pregnancy loss, and preeclampsia.