Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

• 作者: Ying Jin Wei Gu Weichang Chen
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2021,（2）
• 所属期刊栏目: Letter to the Editor
• 页码范围: 151-154
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjaa074

摘要

Dear Editor, p53 acts as a transcription factor to modulate various types of cellular pro-cesses to suppress tumor development(Tackmann and Zhang,2017).The exqui-site regulation of p53 functions is of vital importance for cell fate decisions.Although it is well accepted that p53-mediated cell-cycle arrest,senescence,and apoptosis serve as major tumor sup-pression mechanisms,recent studies suggest that other unconventional activi-ties such as ferroptosis are also critically involved in its tumor suppressor function(Li et al.,2012).