Flavonoids in myocardial ischemia-reperfusion injury:Therapeutic effects and mechanisms

• 作者: Jun-ying Jia Er-huan Zang Li-juan Lv Qin-yu Li Chun-hua Zhang Ying Xia Lei Zhang Lian-sheng Dang Min-hui Li
• 来源期刊: 中草药（英文版）
• 年，卷（期）: 2021,（1）
• 所属期刊栏目: Reviews
• 页码范围: 49-63
• 页数: 15页
• 语种: 英文

摘要

Ischemic heart diseases are one of the major causes of death worldwide.Effective restoration of blood flow can significantly improve patients'quality of life and reduce mortality.However,reperfusion injury cannot be ignored.Flavonoids possess well-established antioxidant properties;They also have other ben-efits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI).In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects.The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects:a)antioxidant,b)anti-inflammatory,c)anti-platelet aggregation,d)anti-apoptosis,and e)myocardial-function regulation activities.We also summarized the effectiveness of flavonoids for MIRI.