Comparison of Risks of Thromboembolism of Drospirenone-Containing and Nondrospirenone -Containing Combined Oral Contraceptive Use: A Meta-Analysis

• 作者: Zhang Wan-Lin Dong Zhe Zhang Jun-Yan Lyu Min-Zhi Zhang Wei Huang Jian-Lei Yang Xin
• 来源期刊: 生殖与发育医学（英文）
• 关键词: Arterial Thromboembolism Combined Oral Contraceptives Drospirenone Venous Thromboembolism
• 年，卷（期）: 2021,（3）
• 所属期刊栏目: Review Article
• 页码范围: 156-160
• 页数: 5页
• 语种: 中文
• DOI: 10.4103/2096-2924.324822

摘要

This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m 2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.